15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism
نویسندگان
چکیده
منابع مشابه
Effects of 15-Deoxy-Δ12,14-Prostaglandin J2 (15d-PGJ2) and Rosiglitazone on Human Vδ2+ T Cells
BACKGROUND Thiazolidinediones (TZD) class of drugs, and 15-deoxy-D12,14-prostaglandin J2 (15d-PGJ2) are immune regulators predicted to modulate human autoimmune disease. Their effects on gammadelta T cells, which are involved in animal model and human and animal autoimmune diseases, are unknown. METHODOLOGY/PRINCIPAL FINDINGS We characterized the activity of rosiglitazone (from the TZD class ...
متن کامل15-Deoxy-Δ12,14-Prostaglandin J2 Protects PC12 cells from LPS-Induced Cell Death Through Nrf2 pathway in PPAR-γ Dependent Manner
Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...
متن کامل15-deoxy-δ12,14-prostaglandin j2 protects pc12 cells from lps-induced cell death through nrf2 pathway in ppar-γ dependent manner
introduction: the inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (cox). cox catalyzes the formation of prostaglandins from arachidonic acid. among prostaglandins, 15-deoxy-d12, 14-prostaglandin j2 (15d-pgj2), an endogenous ligand of peroxisome proliferator-activated receptor-gamma (ppar-γ), has been demonstrated to have anti-inflam...
متن کامل- Prostaglandin J 2 inhibits inflammatory hypernociception : involvement of peripheral opioid receptor
The 15-deoxy-∆-Prostaglandin J2 (15d-PGJ2) is an endogenous ligand of peroxisome proliferator-activated receptors γ (PPAR-γ), and is now recognized as a potent antiinflammatory mediator. However, information regarding the influence of 15d-PGJ2 on inflammatory pain is still unknown. In this study, we evaluated the effect of 15d-PGJ2 upon inflammatory hypernociception and the mechanisms involved ...
متن کامل15-deoxy-Δ12,14-prostaglandin J2 in neurodegenerative diseases and cancers
Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) appear to have no connection with cancers. In the view of cell death, however, common ground can be found between neuronal and non-neuronal diseases [1]. AD and PD are ascribed to the cell death of neurons, which should be alive under healthy conditions. In contrast, cancers are attributed to the proliferat...
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ژورنال
عنوان ژورنال: PPAR Research
سال: 2019
ISSN: 1687-4757,1687-4765
DOI: 10.1155/2019/7242030